If you drive, your car’s tires are shredding more than just tread: they may be mincing up our grey matter too.
New research by a team in China discovered an alarming link between a chemical commonly found in tires and the onset of Alzheimer’s disease. The chemical, called 6PPD-Q, is formed when fine tire particles meet ozone. That happens anytime new chunks of tire are exposed to the air, meaning the particle may be nearly ubiquitous in car-heavy environments.
According to the findings, recently published in the journal Open Medicine, when the ozone-treated chemical meets our brain cells, it can cause oxidative stress — wear and tear, basically — and inflammation, while also reducing how effectively individual cells “communicate” with one another. These factors strongly correlate to the development of early-stage Alzheimer’s, suggesting anyone who regularly comes into contact with rubber tires may be inadvertently exposing themselves to brain-altering chemicals.
For those in car-dependent regions of the world like North America, that’s a pretty significant chunk of the population.
The chemical makes its way into our brains through our blood, which it enters primarily when we breathe in dust particles laden with 6PPD-Q. Other avenues of exposure include crops and soil, stadium turf, working near highways or with cars, and contact with recycled tire products.
While scientists already knew that 6PPD-Q interacts with the brain somehow, the chemical’s newfound molecular connection to Alzheimer’s is significant. Using machine learning software, the team mapped how effectively the chemical binds to five “Alzheimer predictor genes,” finding that 6PPD-Q forms strong bonds with three.
Beyond humans, 6PPD-Q run-off from roadways is having a sizable impact on fish populations, notably salmon. One 2022 study on the environmental journey road runoff takes described the substance as a “highly toxic tire-derived chemical,” which has caused “mass mortalities of coho salmon,” specifically.
Going forward, scientists still need to conduct broader lab tests on human cells in order to figure out how severely various quantities of 6PPD-Q contribute to Alzheimer’s disease. Only then can we get a sense of just how risky it is to burn rubber.
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